Tumor Promotion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Taken together, Ppp6c deficiency enhances K-ras<sup>G12D</sup> -dependent tumor promotion.
|
29758119 |
2018 |
Thyroid Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we focus on the transcriptome difference among PTCs, ATCs and normal tissue from a published dataset including 45 normal tissues, 49 PTCs and 11 ATCs, by applying a machine learning method, maximum relevance minimum redundancy, and identified 9 genes (BCL2, MRPS31, ID4, RASAL2, DLG2, MY01B, ZBTB5, PRKCQ and PPP6C) and 1 miscRNA (miscellaneous RNA, LOC646736) as important candidates involved in the progression of thyroid cancer.
|
24718460 |
2014 |
Thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we focus on the transcriptome difference among PTCs, ATCs and normal tissue from a published dataset including 45 normal tissues, 49 PTCs and 11 ATCs, by applying a machine learning method, maximum relevance minimum redundancy, and identified 9 genes (BCL2, MRPS31, ID4, RASAL2, DLG2, MY01B, ZBTB5, PRKCQ and PPP6C) and 1 miscRNA (miscellaneous RNA, LOC646736) as important candidates involved in the progression of thyroid cancer.
|
24718460 |
2014 |
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
|
27841878 |
2017 |
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
|
30578418 |
2019 |
Squamous cell carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Psoriasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, our data identify NF-κB-induced miR-31 and its target, ppp6c, as critical factors for the hyperproliferation of epidermis in psoriasis.
|
26138368 |
2015 |
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Among the newly identified cancer genes was PPP6C, encoding a serine/threonine phosphatase, which harbored mutations that clustered in the active site in 12% of sun-exposed melanomas, exclusively in tumors with mutations in BRAF or NRAS.
|
22842228 |
2012 |
Pigmented Basal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.
|
26950094 |
2016 |
Metastatic melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Sequencing PP6C from patients with melanoma (233 primary and 77 metastatic specimens) with extended prospective clinical outcome revealed a large number of hotspot mutations in patients with both primary and metastatic melanoma.
|
24336958 |
2014 |
melanoma
|
0.540 |
Biomarker
|
disease |
BEFREE |
These findings support the view that formation of micronuclei rather than chromosome instability alone explains how loss of PPP6C, and more generally mitotic spindle and centrosome defects, can act as drivers for genome instability in melanoma and other cancers.
|
23729733 |
2013 |
melanoma
|
0.540 |
Biomarker
|
disease |
CTD_human |
Among the newly identified cancer genes was PPP6C, encoding a serine/threonine phosphatase, which harbored mutations that clustered in the active site in 12% of sun-exposed melanomas, exclusively in tumors with mutations in BRAF or NRAS.
|
22842228 |
2012 |
melanoma
|
0.540 |
CausalMutation
|
disease |
CGI |
|
|
|
melanoma
|
0.540 |
GeneticVariation
|
disease |
BEFREE |
Additionally, we described a role for PP6C in this process and provided a mechanism for PP6C mutations associated with melanoma.
|
25759478 |
2015 |
melanoma
|
0.540 |
GeneticVariation
|
disease |
BEFREE |
Among patients with primary melanoma with PP6C mutations, patients with stop mutations had significantly shorter recurrence-free survival compared with patients without stop mutations.
|
24336958 |
2014 |
melanoma
|
0.540 |
GeneticVariation
|
disease |
BEFREE |
Among the newly identified cancer genes was PPP6C, encoding a serine/threonine phosphatase, which harbored mutations that clustered in the active site in 12% of sun-exposed melanomas, exclusively in tumors with mutations in BRAF or NRAS.
|
22842228 |
2012 |
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Among the newly identified cancer genes was PPP6C, encoding a serine/threonine phosphatase, which harbored mutations that clustered in the active site in 12% of sun-exposed melanomas, exclusively in tumors with mutations in BRAF or NRAS.
|
22842228 |
2012 |
Malignant neoplasm of thyroid
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we focus on the transcriptome difference among PTCs, ATCs and normal tissue from a published dataset including 45 normal tissues, 49 PTCs and 11 ATCs, by applying a machine learning method, maximum relevance minimum redundancy, and identified 9 genes (BCL2, MRPS31, ID4, RASAL2, DLG2, MY01B, ZBTB5, PRKCQ and PPP6C) and 1 miscRNA (miscellaneous RNA, LOC646736) as important candidates involved in the progression of thyroid cancer.
|
24718460 |
2014 |
Malignant mesothelioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PPP6C, whose mRNA is distinguished with three miR-31-binding sites in its 3'-untranslated region, was consistently down-regulated by miR-31 introduction and up-regulated in clinical MM specimens as compared with matched normal tissues.
|
20463022 |
2010 |
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The downregulation of PPP6C by miR-373 may explain why the expression of miR-373 can promote HCC cell proliferation.
|
21481188 |
2011 |
Immunosuppression
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, we provided novel evidence of miR-31 as an emerging key posttranscriptional regulator of hypertension-associated immunosuppression through targeting ppp6C which is a critical regulator in the differentiation of T<sub>reg</sub> cells.
|
30929511 |
2019 |
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
In conclusion, we provided novel evidence of miR-31 as an emerging key posttranscriptional regulator of hypertension-associated immunosuppression through targeting ppp6C which is a critical regulator in the differentiation of T<sub>reg</sub> cells.
|
30929511 |
2019 |
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the orthotopic mice model, the overexpression of PP6c in GBM U87 cells attenuated the effect of radiation treatment, and reduced the survival time of mice compared with the control mice, while the PP6c knocking-down improved the effect of radiation treatment, and increased the survival time of mice.
|
22158480 |
2011 |
Cutaneous Melanoma
|
0.400 |
CausalMutation
|
disease |
CGI |
|
|
|
Cutaneous Melanoma
|
0.400 |
GeneticVariation
|
disease |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |